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Wednesday, November 20, 2019

Telomeres elongation

Munoz and Blasco at CNIO

Scheme representing the telomeric elongation process associated with the cell division of pluripotent cells and the generation of animals with hyperlong telomeres. Mouse embryonic stem cells are obtained and cultured during a few cell divisions to allow telomeric elongation without any genetic manipulation. After this process, pluripotent cells with hyperlong telomeres are introduced into a recipient embryo with normal cells, thus generating a chimera with two different cell types. These chimeric embryos are reimplanted into mice for the generation of mice in which 100% of their cells are derived from embryonic cells with hyperlong telomeres. /CNIO

Hyper-long telomeres

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